I found this Really Great Windows GUI based,
ROM Patching Tool.
Called IPSWin (International Patching System).
It is really easy to use.
Here is a pic from the site.

All you do is select the file to patch and the patch itself,
and click Patch and you are done.
It even has Options to creat a log and a back up file just in case the Patch
Fails.
There is also a Java based one for thoses that do not have windows.
Here is a pic of the Java IPS from the Site:

Here are some links to the site:
ZeroSoft
IPSWin2.0 (246KB)
JIPS 3.0 (13.6KB)
There are a few other programs there as well.
Take a look.
I will use the this Topic to post any updates that I find on this subject and
Sites Here.
If the MOD's think there is a better place for this topic let me know and go
ahead and move it.
Edit: Please do to some type of Web Loading problem I Copied the pics
above into my On-Line File storage so they would display right.
EDIT2:
I will post here any and all GUI IPS programs that are worthy of use.
Lunar IPS (LIPS) - IPS Creation/Application Tool (97KB)